The bacterial signal molecule, ppGpp, regulates Salmonella virulence gene expression

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The bacterial signal molecule, ppGpp, mediates the environmental regulation of both the invasion and intracellular virulence gene programs of Salmonella.

During infection of mammalian hosts, facultative intracellular pathogens have to adjust rapidly to different environmental conditions encountered during passage through the gastrointestinal tract and following uptake into epithelial cells and macrophages. Successful establishment within the host therefore requires the coordinated expression of a large number of virulence genes necessary for the...

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ژورنال

عنوان ژورنال: Molecular Microbiology

سال: 2004

ISSN: 0950-382X,1365-2958

DOI: 10.1111/j.1365-2958.2004.04122.x